Thayer's Greek Lexicon

 1. to tread
  1) to trample, crush with the feet
  2) to advance by setting foot upon, tread upon: to encounter
successfully the greatest perils from the machinations and
persecutions with which Satan would fain thwart the
preaching of the gospel
  3) to tread under foot, trample on, i.e. to treat with insult
and contempt: to desecrate the holy city by devastation and
outrage