Isaiah saw the hand of God stretched out in judgment against Assyria and the other nations of his time, and knew there was no power in heaven or earth that could turn it back. When God purposes to do something His will shall be accomplished, regardless of the will of man (see Num. 23:19; Job 9:12; Isa. 43:13; Dan. 4:32, 35). These words conclude the message against Assyria.